2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Thyroid Hormone Receptor

Thyroid Hormone Receptor

THR

Thyroid Hormone Receptor

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Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.

Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117167
    KB-141
    		Agonist
    KB-141 is a potent and selective TRβ agonist. The IC50 values are 23.9 nM and 3.3 nM for binding affinities from displacement of T3 from hTRα1 and hTRβ1, respectively. KB-141 has anti-obesity, anti-diabetic, and lipid-lowering effects?and can be used as an anti-cholesteremic agent in vivo.
    KB-141
  • HY-168046
    ALG-055009
    		Agonist
    ALG-055009 is a thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.063 μM. In rats on a high-fat diet, ALG-055009 can lower total cholesterol levels. ALG-055009 can be used in studies related to metabolic dysfunction-associated fatty liver disease.
    ALG-055009
  • HY-118117
    Rovatirelin
    Rovatirelin is an orally active thyrotropin-releasing hormone (TRH) analog. Rovatirelin binds to the human TRH receptor with a Ki value of 702 nM. Rovatirelin can be used to study spinocerebellar degeneration (SCD) .
    Rovatirelin
  • HY-147055
    THR-β agonist 5
    		Agonist 99.85%
    THR-β agonist 5 (compound 54) is a potent THR-β agonist, with an EC50 of <50 nM.
    THR-β agonist 5
  • HY-18341F
    Biotin-(L-Thyroxine)
    Biotin-(L-Thyroxine) is the biotinylated L-Thyroxine (HY-18341). L-Thyroxine is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from Biotin-(L-Thyroxine) (T4).
    Biotin-(L-Thyroxine)
  • HY-W345393
    Trh-gly
    		Agonist
    Trh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin.
    Trh-gly
  • HY-160207
    Elunetirom
    		Agonist
    Elunetirom (MA-JD21 )is a TR-β selective CNS-penetrant TR-β agonist prodrug and can be used for study of major depressive disorder (MDD).
    Elunetirom
  • HY-18341S1
    Thyroxine hydrochloride-13C6
    Thyroxine hydrochloride-13C6 is the 13C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].
    Thyroxine hydrochloride-<sup>13</sup>C<sub>6</sub>
  • HY-P3962
    [Phe2]-TRH
    [Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin.
    [Phe2]-TRH
  • HY-10003A
    1α-Hydroxy-3-epi-vitamin D3
    		Inhibitor 99.30%
    1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion.
    1α-Hydroxy-3-epi-vitamin D3
  • HY-117475
    N-Acetylthyroxine
    		Control
    N-Acetylthyroxine is a thyroid hormone analogue. N-Acetylthyroxine weakly binds to thyroxine-binding globulin (TBG) in isolated human serum.
    N-Acetylthyroxine
  • HY-P10909
    Canvuparatide
    		Agonist
    Canvuparatide (MBX 2109) is a prodrug for parathyroid hormone (PTH) peptide that releases the bioactive PTH[1-32] peptide agonist that retains a fatty acylated lysine (Lys33) at the C-terminus, thereby extending the halflife of Canvuparatide. Canvuparatide can be used for the symptoms of hypoparathyroidism such as hypocalcemia and hyperphosphatemia.
    Canvuparatide
  • HY-136800
    Posatirelin
    		Inhibitor
    Posatirelin, a TRH analog, increases monoamine metabolites in the cerebral cortex, nucleus accumbens, and striatum, and possibly exerts CNS activating effects through a modification of several neurotransmitter systems.
    Posatirelin
  • HY-W010696R
    Reverse T3 (Standard)
    		Agonist
    Reverse T3 (Standard) is the analytical standard of Reverse T3. This product is intended for research and analytical applications. Reverse T3 is a thyroid hormone that can be generated by deiodination of the prohormone thyroxine. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.
    Reverse T3 (Standard)
  • HY-122353
    Orotirelin
    Orotirelin (CG 3509) is a thyrotrophin-releasing hormone (TRH) analogue. Orotirelin can be used in the study of neurological diseases.
    Orotirelin
  • HY-B1664R
    Iopanoic acid (Standard)
    Iopanoic acid (Standard) is the analytical standard of Iopanoic acid. This product is intended for research and analytical applications. Iopanoic acid is an inhibitor of 5'-Deiodinase and also an iodinated contrast medium.
    Iopanoic acid (Standard)
  • HY-B0346R
    Propylthiouracil (Standard)
    		Inhibitor
    Propylthiouracil (Standard) is the analytical standard of Propylthiouracil. This product is intended for research and analytical applications. Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research.
    Propylthiouracil (Standard)
  • HY-A0070AS3
    Liothyronine-d3
    		Activator
    Liothyronine-d3 is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
    Liothyronine-d<sub>3</sub>
  • HY-131499
    Thyroxine methyl ester
    Thyroxine methyl ester is a Thyroxine derivative.
    Thyroxine methyl ester
  • HY-B1234S
    Octinoxate-13C,d3
    		Agonist
    Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo.
    Octinoxate-<sup>13</sup>C,d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity